ABSTRACT

Colon cancer is the second most common cancer for women and the third most common for men. Its morbidity and mortality are increasing as it is the second largest cause of death related to cancer in the developing countries. In this study, the effects of Arachis hypogaea seeds on 1, 2 dimethylhydrazine (DMH)-induced colon carcinogenesis was examined. Four (4) groups of wistar albino mice were used. While the other groups were induced with DMH, group one (1) acted as the positive control group and was fed a normal diet. Group two (2) was induced with DMH only, across a 12 week period. Over the course of a 12-week period, group three (3) was induced with DMH and fed Arachis hypogaea diet. Group four (4) underwent a six-weeks DMH induction procedure before being administered Arachis hypogaea diet following the induction.