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ABSTRACT
Sphenocentrum jollyanum (SJ) is an example of medicinal plant that belong to the member of the plant family Menispermaceae. It is extensively employed in folkloric medicine in the management of various ailments. The incidence of adverse effects and sometimes life threatening conditions emanating from herbal medicines has been reported in studies. In response, it is important to examine the side effects that may be associated with the indiscriminate consumption of S. Jollyanum as treatment option. Toxicity studies were carried out on the stem bark extract of Sphenocentrum jollyanum. The aim of this study was to evaluate the toxicological and biochemical effects of S. Jollyanum stem in Sprague Dawley rats.