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ABSTRACT
Potassium bromate (KBrO3) is an oxidizing agent that is commonly used in cosmetic products (such as permanent hair weaving solutions and dying of textiles), and as a food additive, and is a major tap water pollutant. Extracts from various morphological parts of Annona muricata Linn. (Annonaceae) are widely used medicinally in many parts of the world for the management, control and/or treatment of a plethora of human ailments, including diabetes mellitus (DM). The present study was undertaken to investigate the possible protective effects of A. muricata leaf methanol extract (AME) in bromate-induced toxicity. The animals used were randomly divided into 6 experimental groups each containing 7 rats. Group A rats served as ‘control’ animals and received distilled water in quantities equivalent to the administered volumes of AME and reference drugs' solutions intraperitoneally; where Group 2 was bromate untreated, Group 3 was bromate treated with low dose of the extract, Group 4: bromate treated with medium dose of the extract, Group 5 was bromate treated with high dose of the extract, Group 6 was bromate treated with silymaria. Post-euthanization, hepatic tissues were excised and processed histologically. The findings of this laboratory animal study suggest that A. muricata extract has a protective, beneficial effect on hepatic tissues. There was effective in ameliorating several of the parameters measured that have been adversely affected by KBrO3 especially at the higher doses. This may be ascribed to the strong anti-oxidant properties of this agent, as Annona muricata is a known dietary prebiotic with an established safety profiles in humans, its inclusion in the edible items that may contain KBrO3, such as flour, bread or cakes may be beneficial, especially in countries that allow the use of KBrO3 in food products, or do not enforce laws regarding its banning.
