SYNTHESIS OF 3-FORMYLINDOLE AND DERIVATIVES

ABSTRACT

The synthesis of indole derivatives as a promising therapeutic compound for pharmaceutical interest has been inadequately covered. Therefore, the aim of this research study is the synthesized 3-[2-(4-nitrophenyl) ethenylindole form indole. Here, the formation of 3-[2-(4- nitrophenyl) ethenylindole from indole involved a two-step reaction procedure. First, the indole was subjected to a formylation reaction at the C-3 using the Vilsmeier-Haacks reagent (DMF and POCl3). This led to the formation of 3-formylindole. Subsequently, 3-formylindole was coupled with 4-nitrotoluene in the presence of sodium ethoxide, resulting in a 29.30% yield of 3-[2-(4-nitrophenyl) ethenylindole.