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This study examined the role of Microfinance banks in poverty alleviation in Nigeria between the period of 1995 and 2020 with the objective of finding out the effects of microfinance bank independent variable (microfinance bank assets, microfinance bank loans, microfinance bank investment and number of microfinance banks) on poverty alleviation using real gross domestic product within the period considered using Fully Modified Ordinary Least Squares multivariate analysis. The result of the analysis shows that all the independent variables have a statistically significant positive relationship with the with poverty alleviation except for assets of microfinance banks. We therefore conclude that the independent variables have significant predictive power on poverty alleviation in Nigeria.