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ABSTRACT
Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide, which is used in many plastic industries. In humans, there is a relationship between BPA levels in blood and metabolic disorders, including type 2 diabetes, abnormal liver functions and neurobehavioral problems (e.g., attention deficit and hyperactivity disorder). BPA is also known to Induce toxicity and damage by inflicting oxidative stress which affects vital organs system and the central Nervous system. Naringenin is a flavonoid found in citrus fruits and vegetables. It has been reported to possesses anti-oxidatant, anti-inflammatory and anticancer properties, however it's protective effectagainst BPA toxicity has not been previously reported. This study investigated the protective effect of naringenin in Bisphenol A induced toxicity in Wister rats. Twenty (20) adult Wister rats weighing between 180-250g were employed for this study. The rats were randomly selected in four groups with each group containing five (5) rats (n=5). Control; were fed with rat chow and water ad lithium while group C received BPA (50 mg/kg), NRG (100 mg/kg) respectively and group D were pretreated with naringenin (100 mg/kg) 1 hour before administrating BPA (50 mg/kg). These compound were Administered orally. The experimental period lasted for 28 days after which the animals were sacrificed for biochemical analysis (SOD, CAT, GPx, MDA). Result showed there was a significant decrease in SOD in BPA treated rats when compared with the control (p<0.05) while we observed a significant improvement in SOD in NAR (1hr + BPA) treated groups when compared with the BPA treated group only (p<0.001). we also observed a significant decrease in CAT in BPA treated rats when compared with the control (p<0.05). Catalase activity was significantly improved in NAR (1hr + BPA) treated groups when compared with the BPA treated group. There was a significant decrease in GPx in BPA treated rats when compared with the control (p<0.05). In rats co-treated with NAR (1hr) and BPA, there was a significant improvement in GPx when compared with rats treated with BPA only (p<0.001). We observed a significant increase in MDA activity in BPA treated rats when compared with those of the control indicative that BPA induce lipid peroxidation and oxidative stress while in NAR (1hr + BPA) treated groups. there was a significant reduction in MDA activity when compared with BPA treated rats only (p<0.05). from the result of this study, we can conclude that naringenin displayed rich antioxidant properties by improving the antioxidant status of rats and negate the negative impact of BPA toxicity in rats.
