ABSTRACT
Introduction: Matrix tablet is one of the convenient approaches for the preparation of sustained release dosage forms to improve patient compliance. A sustained release dosage form is designed to release the drug contained therein at a continuous and more controlled rate for a longer period of time than can be normally achieved with conventional dosage forms.
Objective: The objective of this study was to develop and evaluate sustained release tablets of diclofenac potassium prepared by melt granulation technique using okra gum in addition to other polymers (carnauba wax and hydroxylpropylmethyl cellulose) and to optimise the concentration of the polymers using Box-Behnken Design.
Method: Various batches (B1-B9) of diclofenac tablets were prepared by melt granulation technique using Box-Behnken modelled-combinations of three polymers (dry okra gum powder, carnauba wax and hydroxylpropylmethyl cellulose). Powder blends and tablets of the various batches were mass produced and subjected to pre-compression (bulk and tapped densities, angle of repose, Hausner’s ratio and Carr’s index) and post compression (hardness, friability, weight uniformity and dissolution) evaluations respectively.
Results: The powder mixtures of batches had angle of repose between 23.20-27.21°, Hausner’s ratio ranging from 1.12-1.22, Carr’s index between 10.71-18.18% as well as bulk and tapped densities ranging between 0.41-0.60g/cm³ and 0.47-0.64g/cm³ respectively. The nine batches had uniform weight with low standard deviation value within the B.P limits, optimal hardness values (between 4.0 - 12.50Kgf), friability values of 0.60-0.99% (<1%) and they released about 70% of their drug content within 4 hours of dissolution studies.
