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ABSTRACT
Modern scientific research has revealed that Zingiber officinale possesses numerous therapeutic properties including antibiotic, antimicrobial, and antioxidant effects, an ability to inhibit the formation of inflammatory compounds, and direct anti-inflammatory effects. A total of 30 adults Wiistar rat weighing between 120g and 150g were assigned into six groups (A, B, C, D, E and F) of five rats per group. The rats had free access to grower marsh feed (Top feed mills, Nigeria) throughout the experiment. Group A Which served as control were administered 1ml of distilled H2O, Group B were orally administered 10 mg/kg As2O3 only, while group C and D were orally administered aqueous Rhizome extract of Zingiber officinale at doses of 190mg/kg and 380mg/kg body weights and arsenic of 10mg/kg body weights respectively.Group E were administered arsenic of 10mg/kg body weight and 50 mg/kg body weight of standard drug silymarin and Group F were administered high doses of zingiber officinale at 380mg/kg body weight. On the 28th day the rats were sacrificed. At the end of the experiment, the animals were euthanized using chloroform anaesthesia. Their pancreas were harvested and fixed in 10% formal saline and taken to the Histopathology department in the University of Benin Teaching Hospital, Benin City for histological processing using H&E stains for microscopy. Data were subjected to statistical analysis using the IBM SPSS statistics software (statistical package for social science) (Version25) and relevant statistical values were obtained. e-way analysis of variance (ANOVA) was carried out and data were presented as mean ± SEM.LSD post-hoc test were used. Values of P<0.05 were considered significant. The statistical values obtained converted into graphical representations in the form of bar charts. Results of the Biochemical analysis indicated that Zingiber officinale had no significant effects using (P<0.05) in terms of body weight, but a slight increase in pancreatic weight with administration of high doses of the extract and toxicants(arsenic) and moderates the concentration of the haematological parameters as well maintained the oxidative stress on arsenic-intoxicated rats. Histological analysis, indicated that the aqueous Rhizome extracts of Zingiber officinale extract ameliorated the effects of arsenic-intoxicated rats in a reversible dosage dependent pattern.
