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ABSTRACT
The use of traditional medical therapy is an important method in the treatment and management of diseases in the African continent and this could be as a result of social, cultural and economic lifestyles. Pharmacologically, the active ingredients found in pyrenacantha staudtii can be extracted and used to cure and prevent numerous diseases. The aim of this research was to investigate the effect of aqueous extract of pyrenacantha staudtii on the undamaged spleen of adult wistar rats. Thirty adult wistar rats weighing between 110g and 200g were used for this experiment with five rats in each group. All rats were allowed two weeks of acclimatization and they all had equal access to feed and water. Group A was the control and was not administered with any extract. Group B was administered with a low dose of the extract(100mg). Group C was administered with a medium dose of the extract(200mg). Group D was administered with 400mg of the extract. Group E was administered with 800mg of the extract. Group F was administered with 1600mg of the extract. All the rats were administered with the extract for 35 days. On the 36th day, the rats were sacrificed via chloroform anaesthesia and the spleen were harvested immediately and preserved in 10% formal saline for tissue processing using H&E for histological analysis. Blood samples were also collected and were immediately transferred into EDTA bottles for differential analysis. The results of this study showed that there were no significant difference in the body and organ weight of the animals. There were also no significant difference in the hematocrit, white blood cells, red blood cells, haemoglobin etc. The histological slides revealed follicular activation, vasodilation and congestion when compared to control. In conclusion, pyrenacantha staudtii has an immune system stimulating effect and no adverse effect on the spleen of adult Wistar rats.
