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ABSTRACT
The liver is the main organ where exogenous and endogenous chemicals are metabolized and finally excreted. As a consequence, hepatocytes are exposed to remarkable concentrations of these chemicals and drugs, which can lead to cell death, hepatoxicity, liver dysfunction, and even organ failure. During fetal development, the liver plays a crucial role in hematopoiesis, metabolism, and detoxification. Any disruptions or abnormalities in liver development can have long-lasting effects on liver function and overall health. Therefore, understanding the impact of Carbon Tetrachloride (CCl4) exposure on liver histology during fetal development is of significant interest since CCl4 is well-known for its hepatotoxic effects, causing liver damage, inflammation, fibrosis, and even hepatocellular carcinoma. This study was aimed at assessing the histological development of the liver following intrauterine exposure to CCl4. In this study, forty (40) adult Wistar rats weighing between 160 g and 180 g were used. The animals were paired overnight at the estrous cycle with sexually active males in the ratio of 2:1. Estrous cycle was confirmed by vaginal lavage. The presence of vaginal plug and/or sperm in the vaginal smear was GD0. The pregnant rats were divided into two groups (A and B) with twenty (20) rats per group. Group A served as Control and was administered with a single intraperitoneal injection of 0.2 ml of normal saline on GD 8.
