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ABSTRACT
Ekebergia senegalensis has been applied in treatment of inflammatory conditions in African traditional medicine. This application prompted the need for a scientific evaluation of the plant's anti-inflammatory activity. The anti-inflammatory activity of the ethyl acetate fraction of E. senegalensis methanol leaf extract was evaluated using the carrageenan-induced and dextraninduced paw oedema in rats and the croton oil-induced ear oedema in mice. The extract exhibited significant (p<0.05) reductions of paw oedema induced by carrageenan and dextran at doses of 100 and 200 mg/kg . All doses (100 - 500 mg/kg) of the extracts caused significant (p<0.001) but non-dose dependent reductions in croton oil-induced ear oedema, with the highest effect produced by the 200 mg/kg dose. The results of this study suggest that the ethyl acetate fraction of E. senegalensis methanol leaf extract possesses anti-inflammatory properties, which may be beneficial in the treatment of inflammatory disorders
