You have no items in your shopping cart.
ABSTRACT
The escalating exposure to heavy metals due to industrialization and anthropogenic activities has led to adverse health effects. Cadmium is one such metal that can accumulate in biological organisms and disrupt cellular functions. This study aims to evaluate the ameliorative effect of glycine against cadmium-induced kidney damage in adult Wistar rats. Thirty adult Wistar rats were divided into six groups and treated with various combinations of cadmium and glycine. Body weight, kidney weight, organo-somatic index, serum sodium and potassium ion levels, creatinine levels, and total protein levels were measured. Kidney histology was examined using hematoxylin and eosin staining. Cadmium administration resulted in reduced body weight, along with kidney histopathological changes including patchy tubular necrosis, interstitial infiltrates of inflammatory cells, vascular hypertrophy, and interstitial congestion. Glycine administration at 500mg/kg showed ameliorative effects against these cadmium-induced changes, although higher doses (1000mg/kg) did not offer the same effect. The study demonstrates that glycine at a dose of 500mg/kg has an ameliorative effect against cadmium-induced kidney damage in adult Wistar rats. Further investigation is needed to understand the underlying mechanisms of this amelioration and to optimize the dosage for maximum efficacy.
