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ABSTRACT
This study was carried out to determine the wound healing potency of Parkia biglobosa ethanol leaf extract on surgical wounds using animal model. Thirty-two (32) healthy female albino rats (Rattus norvegicus), two months old, with an average weight of about 188g were purchased. Normal excision wounded animals in Group 1 (Control) were only given food and water. Group 2 (Standard drug) were given cicatrin powder to treat their wounds. Group 3 were given 10% Parkia biglobosa extract to treat their wounds. Group 4 were given 20% Parkia biglobosa extract to treat their wounds. After seven days, serum blood samples were taken, analyzed for anti-inflammatory. The results of showed that the extracts of P. biglobosa had positive effect on wounded healing. Tumour necrosis factor (TNF-α) of group 1 animals range from 136.0 pg/ml to 110.5 pg/ml, group 2 animals range from 87.0 pg/ml to 117.6 pg/ml, group 3 animals range from 123.45 pg/ml to 117.6 pg/ml, while group 4 animals range from 116.7 pg/ml to 133.6 pg/ml. The Superoxide dismutase (SOD) values of the treated animals were as follows: group 1 animals range from 12.6 U/mg to 18.95 U/mg, group 2 animals range from 17.85 U/mg to 25.15 U/mg, group 3 animals range from 14.2 U/mg to 23.9 U/mg, while group 4 animals range from 14.8 U/mg to 16.1 U/mg. The study recommends that the potential and safety of this plant extract, as well as their possible protective mechanisms, should be determined before administration into humans.
