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ABSTRACT
In this study,the protective effects of Zingiber officinale in arsenic intoxicated rats were evaluated. Heavy metals are the most toxic pollutants due to their solubility in water and absorption by the living organism. Highly toxic metals cause harmful effects at hematological and organ level. A total of 30 adult Wistar rats weighing between 110g and 200g were assigned into six groups (A, B, C, D, E and F) of five rats per group. The rats had free access to grower mash feed (Top feed mills, Nigeria) throughout the experiment. Group A Which served as control were administered 1ml of distilled H2O, Group B were orally administered 10 mg/kg As2O3 only, while group C and D were orally administered aqueous stem extract of Zingiber officinale at doses of 190mg/kg and 380mg/kg body weights and arsenic of 10mg/kg body weights respectively.Group E were administered arsenic of 10mg/kg body weight and 50mg/kg body weight of standard drug silymarin and Group F were administered high doses of zingiber officinale at 380mg/kg body weight. On the 28th day the rats were sacrificed. At the end of the experiment, the animals were euthanized using chloroform anesthesia. Their kidney were harvested and fixed in 10% formal saline and taken to the Histopathology department in the University of Benin Teaching Hospital, Benin City for histological processing using H&E stains for microscopy. Data were subjected to statistical analysis using the IBM SPSS statistics software (statistical package for social science) (Version25) and relevant statistical values were obtained. e-way analysis of variance (ANOVA) was carried out and data were presented as mean ± SEM.LSD post-hoc tests were used. Values of P<0.05 were considered significant. The statistical values obtained are converted into graphical representations in the form of bar charts. Results of the Biochemical analysis indicated that Zingiber officinale had no significant effects using (P<0.05) in terms of body weight, renal weight,renal somatic index and moderates the concentration of the hematological parameters as well maintained the oxidative stress on arsenic-intoxicated rats. Histological analysis indicated that the aqueous stem extracts of Zingiber officinale extract protected the kidneys from the effects of arsenic-induced rats in a dosage dependent pattern.
