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ABSTRACT
The significant increase in glutathione levels in response to Montelukast and Hydrocortisone treatment suggests a potential positive impact on the antioxidant defense system in asthma-induced Sprague Dawley rats. These findings support the idea that these drugs may help mitigate oxidative stress, which is often associated with asthma. while Montelukast and Hydrocortisone did not significantly affect superoxide dismutase levels, they showed promising potential in increasing glutathione levels, emphasizing their potential therapeutic value in combating oxidative stress in the context of asthma. Further investigations are vital to fully comprehend their mechanisms and optimize their use in asthma management.
