EFFECT OF INTERMITTENT FASTING ON PROTHROMBIN TIME ESTIMATION

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ABSTRACT

Intermittent fasting refers to any of the several meal plans that alternate over a specified amount of time between voluntary fasting (or calorie restriction) and non-fasting. This study was carried out in the University of Benin and environs in Ovia North East local government area, Benin City, Edo state. It was a longitudinal study involving sixty (60) apparently healthy adults both sexes aged18-30years and divided into two phases; the fasting phase for 12 hours (test phase) and nonfasting phase (control phase) who maintained regular eating pattern. Blood samples from the fingertip and applied to the glucose strip indicator region of the glucose strip and accurately inserted into the glucometer for both random and fasting blood glucose analysis. About 5mls of blood samples were collected with minimal trauma via the cubital fossa using a sterile disposable syringe and needle. 4.5ml of blood was dispensed into 0.5ml of sodium citrate anticoagulated container in a ratio of 1:9. Result revealed a significant reduction in the prothrombin time during the fasting phase when compared with the non-fasting phase (p<0.05) due to an increase in clot formation time associated with dehydration. In conclusion intermittent fasting could give an insight into the risk of thrombosis in extended fasting periods if not monitored.

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