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ABSTRACT
Garcinia kola Heckel (Clusiaceae) is a tree indigenous to West and Central Africa. All plant parts, but especially the seeds, are of value in local folklore medicine. Garcinia kola is used in treatment of numerous diseases, including gastric disorders, bronchial diseases, fever, malaria and is used to induce a stimulating and aphrodisiac effect. The plant is now attracting considerable interest as a possible source of pharmaceutically important drugs. Kolaviron is the most studied compound and is perceived by many studies as the active principle of garcinia kola. The aim of the present study is to investigate the effects of the administration of garcinia kola and fat and oil on the weight of male Wistar rats. The materials used for this study are simple weighing scale, laboratory shaw, feeding bowls, plastic cages, clean water, ethanoic aqueous garcinia kola extract, gloves and butter. Forty-six (46) rats weighing between 120g and 200g were divided into five(5)groups; normal control rats,fat and oil supplement, low dose group treated with 25mg/kg garcinia kola, medium dose group treated with 50mg/kg and high dosage group treated with 100mg/kg. Rats were treated for three(3) weeks and their weights were measured at the end of each week. Differences between the weights of each group were assessed using one-way analysis of variance (ANOVA). Data were presented as mean ± standard error of mean. P<0.05 were considered to indicate a statistically significant difference. Results were compared between normal control group, fat and oil supplement and groups treated with garcinia kola (25mg/kg, 50mg/kg and 100mg/kg). Results from the statistical analysis showed a significant increase in weight in the fat and oil supplement and high dose group when compared with the control group. From this previous study, ingestion of Garcinia kola and fat and oil was shown to have an effect on the body weight of the test animals. High dose administration of Garcinia kola increased body weight, while low dose of Garcinia kola did not increase body weight.
