SUMMARY
This present study indicates that effects in cadmium had on renal cells of rats exposed to the toxicant after 21 days and 28 days , cadmium cause acute toxicity in several specie including humans, it primarily affects tissues.
The change in body weight is used as a marker to check the animal health status,a reduction in body weight is an indication of worsening of experimental rats during the experimental period.
At the end of the 21 days experiment, results showed that there was a decrease in change in body weight as well as organ body weight of the group treated with cadmium. However, the difference in their decrease was significant.
Cadmium exposure on kidney cells is well established on the elevated antioxidant levels and selected plasma metabolites indicating the cellular leakage and loss of functional renal membrane architecture .
In this study, antioxidant enzyme activity of Superoxide dismutase (SOD), Catalase (CAT), Malonialdehyde (MDA) were evaluated to determine the effects cadmium had on rat kidney after 28 days of exposure to the toxicant both SOD and CAT have been thought to be the biological marker of antioxidant stress, the antioxidant enzymes are the first line of cellular defense against oxidative injury. While SOD and CAT mutually function in Reactive oxygen specie (ROS) and Reactive nitrogen species (RNS) elimination.
