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ABSTRACT
Fertility is the quality of being able to produce offspring through reproduction following the onset of sexual maturity. Azanza garckeana known as “Gorontula” (Tula Kola nut), it is a deciduous shrub in Gombe State and Morojwa in Botswana, it is a valuable edible indigenous fruit widely distributed in Tula, Kaltungo Local Government Area of Gombe State. The plant extract have been reported to be richly high in saponins, Phenol, tannins, flavonoids and alkaloids. The aim of the study is to investigate the effects of Azanza garckeana (goron tula) on the ovary, placenta and uterus of adult female Wistar rats. Thirty adult female Wistar rats were used for this study. They were randomized into five (5) groups of six (6) rats each. Group A served as control. Group B were allowed to mate and litter. Group C were administered 50mg/kg body weight of Azanza garckeana extract via oral route daily and were allowed to mate and sacrificed after day 19. Group D were administered 50mg/kg body weight of Azanza garckeana extract via oral route daily and were allowed to mate and litter, Group E were administered 50mg/kg body weight of Azanza garckeana extract via oral route daily and were unmated. This experiment spanned for a period of 30 days before sacrifice, except for Group B, after which series of tests such as: statistical analysis, oxidative stress analysis were conducted, weighed and fixed for histopathological analysis. Data were subjected to statistical analysis using the IBM SPSS statistics software (Statistical Package for Social Science) (Version 25) and relevant statistical values were obtained. One-way analysis of variance (ANOVA) was carried out, and data were presented as mean ± SEM. LSD post-hoc test was used. Values of P<0.05 were considered significant. The statistical values obtained were converted into graphical representations in the form of bar charts. The result of study showed that there was significant increase compared to control (P<0.05) as regards body weight. There was no significant different (P>0.05) compared to control on organ weight. The Gorontula treated group had more numbers of litters compared to the Gorontula untreated group. The findings of this study indicates that A. garckeana causes significant increase (P<0.05) in the body weight of rats in all groups, except for rats treated with Goron tula and mated which showed decrease in body weight when compared to the control group.
