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ABSTRACT
Peptic ulcer disease is a set of conditions characterized by ulceration in the upper gastrointestinal tract. Pennisetum pedicellatum have historically been used to cure wounds, pain-related conditions, to feed animals, and to treat parasite diseases and eye infections.
The purpose of this study is to evaluate if Pennisetum pedicellatum alone or in combination with Sorghum bicolor aqueous extract has gastro-protective properties using chemically-induced (ethanol and indomethacin) ulcer model in rats. The reference treatment was ranitidine (100 mg/kg). All extracts and drugs were administered through the oral route. The results were analyzed using one-way analysis of variance(ANOVA) followed by Dunnet post hoc test.
The extract of Pennisetum pedicellatum (100 -500 mg/kg)significantly (p<0.0001) protected against ethanol- and indomethacin-induced ulcerations, with the greatest effect at 100 mg/kg. The extract also significantly reduced the severity of lesions. The aqueous extract of Pennisetum pedicellatum alone or in combination with Sorghum bicolor possesses anti-ulcer properties that may be due to cytoprotective mechanism or neutralization of gastric acid. These findings indicate that Pennisetum pedicellatum could have a beneficial role against ulcers.
