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ABSTRACT
Inflammation causes discomfort, suffering and lower productivity of the victims. Non-steroidal anti-inflammatory drugs which are highly prescribed in medication of inflammation and pyrexia have been reported to possess adverse effects. Herbal medicines may possess bioactive compounds that are safer and efficient in the management of various diseases and disorders. Kigelia africana are traditionally used to manage pyrexia and inflammation but there is little to no scientific data to support their use. The present study determined anti-inflammatory and hematological activities of the extract in animal models to scientifically confirm their traditional use. Fresh fruits of K. africana were gotten from a local herbalist in Benin and transported to the department of Biochemistry, University of Benin for cleaning, air drying, and extraction. Twenty-one male rats (weight range of 130g to 150g) were used for acute toxicity study and was performed following methods by Lorke (1998). Twenty male Wistar rats weighing between 130 - 150 grams were used to test anti-inflammatory activity. The rats were divided randomly into ten groups of two wistar rats each and treated as follows; Group I (normal control) was not induced with paw edema but received 1 mL of distilled water. Group II (negative control) was induced with paw edema and 1 mL of distilled water. Group III was induced with paw edema and received diclofenac (reference drug) at a dose of 10mg/kg body weight. Group IV was induced with paw edema and received dexamethasone (reference drug) at a dose of 10mg/kg body weight. Group V was induced with paw edema and received aspirin (reference drug) at a dose of 10mg/kg body weight. Group VI was induced with paw edema and received the extracts at a dosage of 200 mg/kg. Group VII was induced with paw edema and received the extracts at a dosage of 400 mg/kg. Group VIII was induced with paw edema and received the extracts at a dosage of 600 mg/kg.
