AMELIORATIVE EFFECT OF L-DOPA ON BISPHENOL-A INDUCED WISTAR RAT

ABSTRACT

L-Dopa is used to treat neurotoxic conditions and increase dopamine levels for the treatment of Parkinson's disease (PD). Recent researches shows that Bisphenol A is capable of possessing neurotoxic and neuroplasticity effect on the body, increasing oxidative stress which has been linked to several neurological diseases (i.e., Parkinson's disease, Alzheimer's disease (AD) etc). Eweda et al exposed male rats to Bisphenol A and showed that Bisphenol A contributed to neurological disorders, but the underlying mechanisms could not be completely understood. This research aimed to determine the ameliorative effect of L-Dopa on Bisphenol A induced wistar rat. The specific objectives measured the concentration of superoxide dismutase (SOD), catalase (CAT), gluthathione peroxidase (GST) and malondehyde (MDA) or H2O2. Twenty (20) adult wistar rats weighing between 180 – 250kg were purchased from the Animal House of The Department of Anatomy, University of Benin, Nigeria. The rats were randomly selected in four groups with group A, B, C and D containing 5 rats (n=5) each. Group A was the control fed with rat chow and water ad libitium, Group B animals received BPA (50mg/kg) intraperitoneally for 28 days, group C was treated with L-Dopa (100 mg/kg) intraperitoneally for 28 days and group D was treated with BPA (50mg/kg) for 14 days, thereafter, L-DOPA (100mg/kg) was also administered for another 14 days intraperitoneally. Results shows that for SOD, there is a significant decrease in BPA only group in relation to group 1 (control) while for group 4 (BPA 14D + L-DOPA 14D) there is a significant increase when compared to group 2 (BPA only). For CAT, there is a significant increase in group 2 (BPA only) when compared to group 1 (control) while there is a significant increase in group 4 (BPA 14D + L-DOPA 14D) when compared to group 2 (BPA only).