ABSTRACT

Acute toxicity studies are fundamental in assessing the immediate effects of substances on living organisms. Clopidogrel, a widely prescribed antiplatelet agent, has demonstrated therapeutic efficacy and is widely prescribed by physicians. This study aimed at establishing the LD₅₀ of clopidogrel (brand name Poco) and assessing the effect of administered doses on some liver enzymes in murine model. Acute toxicity model as described by Lorcke’s. Varying doses from 10, 100, 1000, 1500, 2900 and 5000 mg/Kg.bw of clopidogrel was administered according to Lorcke’s model. None of the animals in the exposed groups showed signs of toxicity, and none died. The AST, ALT and ALP activities in liver homogenate for all animals employed in the study were estimated. AST, ALT and ALP activities showed no statistical difference (p>0.05) when comparison was made between control group and within groups administered varying doses of clopidogrel. With no toxicity observed, this study suggest the safety of clopidogrel (poco) over the dose administered.