ACUTE ANTI-STRESS PROPERTIES OF FORMULATED POLYHERBAL TEA (Curcuma longa, Moringa Oleifera, Zingiber officinale, Citrus limon and Allium Sativum)

ABSTRACT

Herbal formulation , sometimes known as "Polyherbal Formulations," have drawn considerable interest. The aim of this study is to evaluate the anti-stress activity of poly-herbal formulated tea (Curcuma longa, Moringa Oleifera, Zingiber officinale, Citrus limon and Allium Sativum). This study was evaluated using tail suspension test, force swimming test and cold restraint stress test. In the tail suspension test, the polyherbal formulated tea at 10 mg/kg and fluoxetine reduced the time of immobility when compared with stress control. (**P<0.01; *P<0.05). In force swimming, the polyherbal formulated tea at 5 mg/kg and fluoxetine at 20 mg/kg significantly increased swimming time when compared with stress control. (****P<0.0001; *P<0.05). In the cold restraint stress test, the polyherbal formulated tea, at 5 mg/kg and 10 mg/kg, reduced the cortisol level in mice when compared with acute stress control. (*P<0.05). The polyherbal formulated tea at 5 mg/kg, 10 mg/kg and fluoxetine at 20mg/kg significantly reduced malondialdehyde levels in mice when compared to stress control. (**P<0.01; *P<0.05). At 5 mg/kg, 10 mg/kg polyherbal formulated tea and fluoxetine 20 mg/kg significantly increased SOD levels, and at 5 mg/kg, 10 mg/kg polyherbal formulated tea increased catalase concentration in animals when compared with stress control. (**P<0.01; *P<0.05) (**P<0.01; *P<0.05). In conclusion, the polyherbal formulated tea possesses antistress properties.